|
|
 |
| TGF-b1和smad4mRNA在慢性肝炎、肝硬化、肝癌癌旁组织的表达及意义 |
|
|
 |
|
TGF-b1和smad4mRNA在慢性肝炎、肝硬化、肝癌癌旁组织的表达及意义 |
|
|
| 作者：佚名 文章来源：世界华人消化杂志 点击数： 更新时间：2004-11-1 15:18:42 |
| 广告载入中... |
|
S: Increased expression of TGF-b1 and smad4 mRNA in the intermediate degree of chronic virus hepatitis and hepatocirrhosis; the positive rates of TGF-b1 and smad4 mRNA were obviously higher in the chronic virus hepatitis and hepatocirrhosis (83.3%, 87.0% and 87.5%, 87.0%) than those in the normal liver (20.0%, 20.0%), the expression of TGF-b1 and smad4 mRNA had a significant relationship between the intermediate degree of chronic virus hepatitis, hepatocirrhosis and the normal liver (b3P <0.01, x2=12.3980; b4P <0.01, x2=14.0 609; b1P <0.01, x2 =14.6 953; b2P <0.01, x2=14.0 609); the expression of TGF-b1 and smad4 mRNA in pare-cancerous tissues were significantly lower than that in the chronic virus hepatitis and hepatocirrhosis, as comparied with with the normal liver; the expression of TGF-b1 and smad4 mRNA reached the highest level at the stage S3, and decreased slightly at the stage S4, with positive relevance (x2 =4.5 064, P =0.0 336, r =0.2 668), in which most of the positive cells were distributed surroundings of portal tract, central vein, and the sinus.
CONCLUSION: TGF-b/smad pathway plays a significant role in formation and development of hepatic fibrosis, and the localization of TGF-b1 and smad4mRNA in hepatic tissue section can be used to evaluate accurately situation and tendency of hepatic fibrosis.
Liao D, Luo GH, Wu JZ, Jiang JN, Huang YQ. Expression of TGF-b1 and smad4mRNA in chronic hepatitis, liver cirrhosis, hepatocellular carcinoma and para-cancerous tissues, and their significance. Shijie Huaren Xiaohua Zazhi 2004;12(9):2091上一页 [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] ... 下一页 >>
|
上一篇文章： 肝纤维化发生发展过程中肝温度的变化规律
下一篇文章： [转载]各种传染病的诊断 |
|
【发表评论】【加入收藏】【告诉好友】【打印此文】【关闭窗口】
|
 |
|
 |
|
|
|
