transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro
progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells. FEBS Lett
2001;502:4-10
10 Inagaki Y, Mamura M, Kanamaru Y, Greenwel P, Nemoto T, Takehara K, Ten Dijke P, Nakao A. Constitutive
phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated
hepatic stellate cells. J Cell Physiol 2001;187:117-123
11 Liu C, Gaca MD, Swenson ES, Vellucci VF, Reiss M, Wells RG. Smads 2 and 3 are differentially activated by transforming
growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells.Constitutive nuclear localization of Smads
in activated cells is TGF-beta-independent. J Biol Chem 2003;278:11721-11728
12 Lee DK, Park SH, Yi Y, Choi SG, Lee C, Parks WT, Cho H, de Caestecker MP, Shaul Y, Roberts AB, Kim SJ. The hepatitis B
virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential
mechanism of hepatitis B virus-induced liver fibrosis. Genes Dev 2001;15:455-466
13 Shen H, Huang G, Hadi M, Choy P, Zhang M, Minuk GY, Chen Y, Gong Y. Transforming growth factor-beta1
downregulation of Smad1 gene expression in rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol
2003;285:G539-546
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