Expression of TGF-b1 and smad4 mRNA in chronic hepatitis, liver cirrhosis, hepatocellular carcinoma and para-cancerous tissues, and their significance
Dan Liao, Guang-Han Luo, Ji-Zhou Wu, Jian-Ning Jiang, Yu-Quan Huang
Dan Liao, Guang-Han Luo, Ji-Zhou Wu, Jian-Ning Jiang, Department of Infectious Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning 530027, China
Yu-Quan Huang, Department of Pathology, The First Affiliated Hospital, Guangxi Medical University, Nanning 530027, China
Correspondence to: Jian-Ning Jiang, Department of Infectious Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning 530027, Guangxi Zhuang Autonomous Region, China. jjning@yahoo.uk.cn
Received: 2004-06-16 Accepted: 2004-07-27
Abstract
AIM: Transforming growth factor b1 (TGF-b1) signaling pathway is involved in a variety of important cellular regulative functions. including cell growth, differentiation, adhesion migration, extracellular matrix formation and immune regulation. The study was aimed to evaluate the relationship and mechanism of transforming growth factor b1 protein and smad4 mRNA in formation and development of fibrosis by detecting the expression of transforming growth factor b1 protein and smad4 mRNA in liver biopsy of chronic virus hepatitis, hepatocirrhosis and para-cancerous tissues.
METHODS: In situ hybridization and immunohistochemistry were used in 10 cases of normal liver tissue, 17 cases of para-cancerous tissues, 70 cases of chronic virus hepatitis and hepatocirrhosis.
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